BACKGROUND: Cases of anti-aquaporin (AQP)-4 antibody-positive familial neuromyelitis optica (NMO) in mothers and daughters are described. PARTICIPANTS: The demographic, clinical, neuroimaging, and anti-AQP-4 antibody status were investigated in four patients from two Asian families with anti-AQP-4 antibody-positive NMO
Varieties of autoantibodies are known to relate to autoimmune neurological disorders as the diagnostic and therapeutic markers. Some of them affected directly to the pathomechanisms of neurological diseases
Background: Neuromyelitis optica (NMO) is a severe demyelinating disease often leading to serious disability. Accumulating evidence now implicates humoral mechanisms in its pathogenesis.
OBJECTIVE: To investigate serum uric acid (UA) levels and related clinical characteristics of neuromyelitis optica (NMO). METHODS: The serum uric acid levels were measured in 65 patients with NMO, compared to control groups which were 76 cases with multiple sclerosis (MS), 126 cases with cerebral vascular diseases (CVD) and 130 healthy controls (HC). The disability severity in NMO was assessed by the Expanded Disability Status Scale (EDSS).
Background: Neuromyelitis optica (NMO) is characterized by severe optic neuritis and transverse myelitis. Aquaporin-4 (AQP4) antibody is a diagnostic biomarker of NMO
Background: Neuromyelitis optica (NMO) is a neurological disease characterized by optic neuritis and transverse myelitis with long spinal cord lesion. Recently, NMO-IgG, which recognizes the aquaporin-4 (AQP-4), was identified in sera from patients with NMO. AQP-4 is a water channel expressed in astrocytes and ependymal cells throughout the brain and spinal cord
Objectives: Neuromyelitis optica (NMO) is an uncommon but life-threatening demyelinating disorder. With the discovery of the NMO antibody in 2004, diagnostic criteria have been revised
OBJECTIVE: To characterize factors that contribute to symptomatic narcolepsy and excessive daytime sleepiness in neuromyelitis optica and multiple sclerosis. SETTING: Japanese university hospitals.
Abstract: Neuromyelitis optica (NMO), or Devic disease, has been distinguished from multiple sclerosis (MS) by the presence of optic neuritis that is usually bilateral, simultaneous, and often severe, myelopathic findings accompanied by longitudinally extensive spinal cord imaging abnormalities, no brain imaging abnormalities typical of MS, and often rapid progression to debility and even death. Researchers at the Mayo Clinic have identified an immunoglobulin marker of NMO (the NMO antibody) that binds selectively to the aquaphorin-4 water channel and may play a causative role
OBJECTIVE:To investigate the characteristics of the linear lesions and longitudinally extensive spinal cord (LESC) lesions in Chinese patients with neuromyelitis optica (NMO).
Neuromyelitis optica (NMO) is a severe inflammatory CNS disorder of putative autoimmune aetiology, which predominantly affects the spinal cord and optic nerves. Recently, a highly specific serum reactivity to CNS microvessels, subpia and Virchow–Robin spaces was described in patients with NMO [called NMO–IgG (NMO–immunoglobulin G)]
Neuromyelitis optica is a severe, inflammatory, demyelinating disease of the central nervous system characterized by attacks of myelitis and optic neuritis.