Julien Ratelade 1 , Jeffrey L. Bennett 2 , A
Genetic analysis of aquaporin-4 in neuromyelitis optica. Matiello M , Schaefer-Klein JL , Hebrink DD , Kingsbury DJ , Atkinson EJ , Weinshenker BG ; On behalf of the NMO Genetics Collaborators
Published: October 2011 Myasthenia Gravis during the Course of Neuromyelitis Optica Masoud Etemadifar a–d , Seyed-Hossein Abtahi a–c , Alireza Dehghani a,e , Mohammad-Ali Abtahi a,e , Mojtaba Akbari a,f , Nasim Tabrizi a,d , Tannaz Goodarzi g a Medical School, Isfahan University of Medical Sciences, b Isfahan Medical Students Research Committee (IMSRC), c Isfahan Research Committee of Multiple Sclerosis, d Department of Neurology, Medical School, Isfahan University of Medical Sciences, e Ophthalmology Ward, Feiz Hospital, Isfahan University of Medical Sciences, f Department of Epidemiology and Statistics, Isfahan University of Medical Sciences, Isfahan, and g National Institute of Genetic Engineering and Biotechnology, Department of Plant Biotechnology, Canker Group, Tehran, Iran Address of Corresponding Author Case Rep Neurol 2011;3:268-273 (DOI: 10.1159/000334128) ? ? Key Words Neuromyelitis optica Devic’s syndrome Myasthenia gravis Multiple sclerosis Aquaporin-4 Interferon Thymectomy ? ? Abstract Neuromyelitis optica (NMO) is an inflammatory demyelinating disorder of the central nervous system that has been thought to be a severe subtype of multiple sclerosis for a long time. The discovery of aquaporin-4 (AQP4) antibody as a highly specific marker responsible for the pathogenesis of NMO, not only has made a revolutionary pace in establishing a serologic distinction between the two diseases, but it has also classified NMO as an antibody-mediated disorder. Similarly, myasthenia gravis (MG) is a well-known antibody-mediated disorder
Multiple sclerosis: pathology and pathogenesis Monday, May 30, 2011, 17:15 – 18:15 The pathology of fulminant neuromyelitis optica with extremely high level of serum anti aquaporin 4 antibody K. Maruyama, M.
Dujmovic I, Mader S, Schanda K, Deisenhammer F, Stojsavljevic N, Kostic J, Berger T, Drulovic J, Reindl M? Temporal dynamics of cerebrospinal fluid anti-aquaporin-4 antibodies in patients with neuromyelitis optica spectrum disorders. [JOURNAL ARTICLE] J Neuroimmunol 2011?Feb?10. Neuromyelitis optica spectrum disorders (NMOSD) are associated with anti-aquaporin-4 autoantibodies (AQP4-IgG).
In 1894, Eug?ne Devic (1858–1930) described a 45-year-old female hatter in whom ‘l’autopsie r?v?la l’existence d’un foyer de my?lite aigu? diffuse localis?e ? la r?gion du renflement lombaire et d’une n?vrite optique double bien marqu?e’ … the autopsy showed a focus of acute diffuse myelitis localized to the lumbar enlargement, as well as a distinct bilateral optic neuritis (Devic, 1894 ). He called the condition ‘neuromy?lite optique aig?e’
Long-term follow-up of patients with neuromyelitis optica after repeated therapy with rituximab. Pellkofer HL , Krumbholz M , Berthele A , Hemmer B , Gerdes LA , Havla J , Bittner R , Canis M , Meinl E , Hohlfeld R , Kuempfel T
Hua Zhang PhD 1 , Jeffrey L. Bennett MD, PhD 2 , A. S
Analysis of 103 Hungarian patients with neuromyelitis optica spectrum disease M. Banati, E. Koszegi, P
Quantification and Functional Characterization of Antibodies to Native Aquaporin 4 in Neuromyelitis Optica Sudhakar Reddy Kalluri, MSc; Zsolt Illes, MD; Rajneesh Srivastava, MSc; Bruce Cree, MD; Til Menge, MD; Jeffrey L. Bennett, MD, PhD; Achim Berthele, MD; Bernhard Hemmer, MD Arch Neurol.
Koji Shinoda Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan Takuya Matsushita Department of Clinical Neuroimmunology, Graduate School of Medical Sciences, Kyushu University, Japan Konosuke Furuta Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan Noriko Isobe Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan Tomomi Yonekawa Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan Yasumasa Ohyagi Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan Jun-ichi Kira kira@neuro.med.kyushu-u.ac.jp Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan Abstract This report describes, for the first time, an occurrence of wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) in a 19-year-old female with neuromyelitis optica (NMO) spectrum disorder, who had anti-aquaporin-4 (AQP4) antibody. A high signal intensity lesion on T2-weighted MRI was detected in the midbrain tegmentum adjacent to the aqueduct, and presumably involved the medial longitudinal fasciculus bilaterally at the caudal levels. Plasma exchange resolved both WEBINO syndrome and the midbrain lesion
OBJECTIVE: To investigate an association between serum B cell activating factor of TNF family (BAFF) levels and anti-aquaporin-4 (AQP4) antibody titers in patients with neuromyelitis optica (NMO) after rituximab treatment. BACKGROUND: Anti-AQP4 antibodies are present in approximately 70% of NMO patients. Such antibodies are probably pathogenic and the titers are elevated during relapse as compared with those in remission.