J Neurol. 2017 Mar 13. doi: 10.1007/s00415-017-8445-8. [Epub ahead of print] Whittam D, Wilson M, Hamid S, Keir G, Bhojak M, Jacob A. The evolution…
Arch Neurol. 2012 Jul 2:1-7. doi: 10.1001/archneurol.2012.1300
Painful Tonic Spasm in Neuromyelitis Optica Incidence, Diagnostic Utility, and Clinical Characteristics Sung-Min Kim, MD; Min Jin Go, MS; Jung-Joon Sung, MD, PhD; Kyung Seok Park, MD, PhD; Kwang-Woo Lee, MD, PhD Arch Neurol.
Neuromyelitis optica in Japanese sisters.
Sudhakar Reddy Kalluri 1 , Veit Rothhammer 1 , Ori Staszewski 2 , Rajneesh Srivastava 1 , Franziska Petermann 1 , Marco Prinz 2 , Bernhard Hemmer 1 , Thomas Korn 1 * 1 Department of Neurology, Klinikum rechts der Isar, Technische Universit?t M?nchen, M?nchen, Germany, 2 Department of Neuropathology, Institute of Pathology, Universit?tsklinikum Freiburg, Freiburg, Germany Abstract? Background Antibodies to the water channel protein aquaporin-4 (AQP4), which is expressed in astrocytic endfeet at the blood brain barrier, have been identified in the serum of Neuromyelitis optica (NMO) patients and are believed to induce damage to astrocytes. However, AQP4 specific T helper cell responses that are required for the generation of anti-AQP4 antibodies and most likely also for the formation of intraparenchymal CNS lesions have not been characterized.
Genetic analysis of aquaporin-4 in neuromyelitis optica. Matiello M , Schaefer-Klein JL , Hebrink DD , Kingsbury DJ , Atkinson EJ , Weinshenker BG ; On behalf of the NMO Genetics Collaborators
Published: October 2011 Myasthenia Gravis during the Course of Neuromyelitis Optica Masoud Etemadifar a–d , Seyed-Hossein Abtahi a–c , Alireza Dehghani a,e , Mohammad-Ali Abtahi a,e , Mojtaba Akbari a,f , Nasim Tabrizi a,d , Tannaz Goodarzi g a Medical School, Isfahan University of Medical Sciences, b Isfahan Medical Students Research Committee (IMSRC), c Isfahan Research Committee of Multiple Sclerosis, d Department of Neurology, Medical School, Isfahan University of Medical Sciences, e Ophthalmology Ward, Feiz Hospital, Isfahan University of Medical Sciences, f Department of Epidemiology and Statistics, Isfahan University of Medical Sciences, Isfahan, and g National Institute of Genetic Engineering and Biotechnology, Department of Plant Biotechnology, Canker Group, Tehran, Iran Address of Corresponding Author Case Rep Neurol 2011;3:268-273 (DOI: 10.1159/000334128) ? ? Key Words Neuromyelitis optica Devic’s syndrome Myasthenia gravis Multiple sclerosis Aquaporin-4 Interferon Thymectomy ? ? Abstract Neuromyelitis optica (NMO) is an inflammatory demyelinating disorder of the central nervous system that has been thought to be a severe subtype of multiple sclerosis for a long time. The discovery of aquaporin-4 (AQP4) antibody as a highly specific marker responsible for the pathogenesis of NMO, not only has made a revolutionary pace in establishing a serologic distinction between the two diseases, but it has also classified NMO as an antibody-mediated disorder. Similarly, myasthenia gravis (MG) is a well-known antibody-mediated disorder
Pathogenic T cell responses against aquaporin 4. Pohl M , Fischer MT , Mader S , Schanda K , Kitic M , Sharma R , Wimmer I , Misu T , Fujihara K , Reindl M , Lassmann H , Bradl M . Source Department of Neuroimmunology, Center for Brain Research, Medical University Vienna, Spitalgasse 4, 1090, Vienna, Austria.
Abstract Neuromyelitis Optica (NMO) is a rare neuroinflammatory disorder with limited epidemiological data. Antibodies against aquaporin-4 (Aq4ab) are reported to be highly specific for NMO and NMO spectrum disorders (NMO-SD).
Fazio R et al. – Neuromyelitis optica (NMO) is a rare demyelinating disease, affecting selectively the optic nerve and the spinal cord. It was previously considered to be a severe variant of multiple sclerosis (MS) due to the similar pathological features and its resemblance to optico–spinal, or Japanese, MS, typical of Asian populations.
Hypothermia, Hypotension, Hypersomnia, and Obesity Associated With Hypothalamic Lesions in a Patient Positive for the Anti-aquaporin 4 Antibody: A Case Report and Literature Review. Suzuki K, Nakamura T, Hashimoto K, Miyamoto M, Komagamine T, Nagashima T, Izawa N, Kanbayashi T, Takahashi T, Hirata K. Abstract OBJECTIVE To describe a patient positive for the anti-aquaporin 4 antibody with hypothalamic lesions showing hypothermia, hypotension, hypersomnia, and obesity.
Anti–Aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica Lukmanee Tradtrantip PhD 1 , Hua Zhang PhD 1 , Samira Saadoun PhD 2 , Puay-Wah Phuan PhD 1 , Chiwah Lam BS 3 , Marios C.