Edgar Carnero Contentti 1, Jorge Correale 2 Affiliations expand PMID: 34530847 PMCID: PMC8444436 DOI: 10.1186/s12974-021-02249-1 Abstract Neuromyelitis optica (NMO) is a chronic inflammatory autoimmune disease…
Acta Neuropathol. 2017 Feb 9. doi: 10.1007/s00401-017-1682-1. [Epub ahead of print] Guo Y1, Weigand SD2, Popescu BF3, Lennon VA1,4,5,6, Parisi JE1,4, Pittock SJ1,6, Parks NE1,…
J Neuroinflammation. 2016 Dec 1;13(1):301. Liu Y, Harlow DE, Given KS, Owens GP, Macklin WB, Bennett JL. Abstract BACKGROUND: Studies of neuromyelitis optica (NMO), an…
Clin Chim Acta. 2016 Jan 30;453:131-3. doi: 10.1016/j.cca.2015.12.013. Epub 2015 Dec 11. Uzawa A, Mori M, Uchida T, Masuda H, Ohtani R, Kuwabara S. BACKGROUND:…
J Neuroimmunol. 2015 Dec 15;289:1-7. doi: 10.1016/j.jneuroim.2015.10.002. Epub 2015 Oct 8. Horellou P, Wang M, Keo V, Chrétien P, Serguera C, Waters P, Deiva K….
Anti-Aquaporin-4 monoclonal antibody blocker therapy for neuromyelitis optica. Tradtrantip L , Zhang H , Saadoun S , Phuan PW , Lam C , Papadopoulos MC , Bennett JL , Verkman AS . Source Departments of Medicine and Physiology, University of California, San Francisco, CA
Takeshi Matsuoka 1,2 , Satoshi O.
Abstract Aquaporin-4 (AQP4) is a water-selective transporter expressed in astrocytes throughout the central nervous system, as well as in kidney, lung, stomach and skeletal muscle.
Neuromyelitis optica is an inflammatory demyelinating disease of the central nervous system associated with autoantibodies against the glial water channel protein aquaporin-4. It has recently been reported that immunoglobulin from neuromyelitis optica patients injected peripherally does not cause lesions in naive rats, but only when pre-existing central nervous system inflammation is present
The complement system is essential in the pathogenesis of inflammatory central nervous system disorders.
Devic’s neuromyelitis optica is an inflammatory demyelinating disorder normally restricted to the optic nerves and spinal cord. Since the identification of a specific autoantibody directed against aquaporin 4, neuromyelitis optica-immunoglobulin G/aquaporin 4 antibody, neuromyelitis optica has been considered an entity distinct from multiple sclerosis
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) while neuromyelitis optica (NMO) is an inflammatory disease of the CNS that selectively affects the optic nerves and spinal cord. In Asians, MS is rare; however, when it appears, the selective and severe involvement of the optic nerves and spinal cord is characteristic. This form, termed opticospinal MS (OSMS), has similar features to the relapsing form of NMO in Western populations