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Genetic analysis of aquaporin-4 in neuromyelitis optica. Matiello M , Schaefer-Klein JL , Hebrink DD , Kingsbury DJ , Atkinson EJ , Weinshenker BG ; On behalf of the NMO Genetics Collaborators
Dian He a , c , Qizhu Wu b , Xiuying Chen a , Daidi Zhao a , Qiyong Gong b and Hongyu Zhou a , , a Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China b Department of Radiology, Huaxi MR Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China c Department of Neurology, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou Province, China Accepted 27 May 2011.? Available online 1 July 2011. ? Abstract The objective of this study investigated cognitive impairments and their correlations with fractional anisotropy (FA) and mean diffusivity (MD) in patients with neuromyelitis optica (NMO) without visible lesions on conventional brain MRI during acute relapse.
Washington, Feb 12 (ANI): Scientists have discovered a new technology to diagnose Alzheimer’s disease from blood samples long before symptoms appear. ? The new method uses synthetic molecules to seek out and identify disease-specific antibodies and could be a big help in diagnosing Parkinson’s disease and immune system-related diseases like multiple sclerosis and lupus, the researchers predict. ? “If we can find a way to detect the disease in its earliest stages – before cognitive impairment begins – we might be able to stop it in its tracks by developing new treatment strategies,” said Dr
Objective In neuromyelitis optica (NMO), the destruction of the blood-brain barrier (BBB) has been considered to be the first step of the disease process.
Objective: To compare spinal cord diffusion tensor imaging (DTI) between multiple sclerosis (MS) and neuromyelitis optica (NMO) subjects with a remote clinical episode of transverse myelitis (TM).
Background: Neuromyelitis Optica (NMO) serology is a powerful tool for differential diagnosis from Multiple Sclerosis (MS). This study aims to perform a post-marketing evaluation of the first indirect immunofluorescence assay (IIFA) commercially available for NMO serology
Background: Despite similarities, neuromyelitis optica (NMO) can be distinguished from multiple sclerosis (MS) by clinical, radiological and serological findings.
The glial water channel aquaporin-4 (AQP4) is implicated in the control of ion and osmohomeostasis in the sensory retina. Using retinal slices from AQP4-deficient and wild-type mice, we investigated whether AQP4 is involved in the regulation of glial cell volume under altered osmotic conditions.
Background: Association of the HLA-DRB1*1501 allele with multiple sclerosis is well established, but its association with neuromyelitis optica has only been evaluated in small populations. Methods: We performed a case-control genetic association study to evaluate the association of HLA-DRB1*1501 with neuromyelitis optica. The single nucleotide polymorphism rs3135388, which tags HLA-DRB1*1501, was genotyped in 164 patients with neuromyelitis optica, 220 patients with multiple sclerosis and 959 controls matched for age, gender and ethnicity
OBJECTIVE: Severe inflammation and astrocyte loss with profound demyelination in spinal cord and optic nerves are typical pathological features of neuromyelitis optica (NMO).
Abstract Background: Neuromyelitis optica (NMO, Devic syndrome) is an inflammatory disorder of the central nervous system of putative autoimmune etiology that primarily affects the optic nerves and spinal cord. NMO is frequently associated with immunoglobulin G (IgG) antibodies to aquaporin-4 (AQP4-IgG), which are thought to be involved in the pathogenesis of the disease