Abstract Autologous peripheral hematopoietic stem cell transplantation (APHSCT) was performed to treat a patient with neuromyelitis optica. We observed that the patient achieved clinical remission after APHSCT during 12 months of follow-up. The patient improved on the expanded disability status scale neurologic assessment and the Scripps neurologic rating scale worksheet scores on follow-up examination compared with baseline.
Quantification and Functional Characterization of Antibodies to Native Aquaporin 4 in Neuromyelitis Optica Sudhakar Reddy Kalluri, MSc; Zsolt Illes, MD; Rajneesh Srivastava, MSc; Bruce Cree, MD; Til Menge, MD; Jeffrey L. Bennett, MD, PhD; Achim Berthele, MD; Bernhard Hemmer, MD Arch Neurol.
BACKGROUND: Antibodies targeting membrane proteins play an important role in various autoimmune diseases of the nervous system.
Neuromyelitis optica (NMO) is an inflammatory disease mainly affecting the optic nerve and spinal cord.