Diagnostic utility of NMO/AQP4-IgG in evaluating CNS inflammatory disease in Thai patients. Apiwattanakul M, Asawavichienjinda T, Pulkes T, Tantirittisak T, Hemachudha T, Horta ES, Jenkins SM, Pittock SJ. Source Department of Neurology, Prasat Neurological Institute, Bangkok, Thailand
Painful Tonic Spasm in Neuromyelitis Optica Incidence, Diagnostic Utility, and Clinical Characteristics Sung-Min Kim, MD; Min Jin Go, MS; Jung-Joon Sung, MD, PhD; Kyung Seok Park, MD, PhD; Kwang-Woo Lee, MD, PhD Arch Neurol.
Neuromyelitis optica (NMO) is an inflammatory demyelinating disorder characterized by optic neuritis and acute myelitis. A parainfectious pathogenesis may play a partial role in the development of this disorder.
The clinical course of immune mediated optic neuritis (ON) will depend on the specific underlying inflammatory disease. These disorders have traditionally been classified according to clinical and MRI findings. Aquaporin-4 (AQP4) autoantibodies (neuromyelitis optica-IgG (NMO-IgG)) may have diagnostic and prognostic value in patients who present with isolated ON.
A 21-year-old right-handed woman suffered cervical myelitis in 1971, followed by two episodes of bilateral optic neuritis and four relapses of thoracic or lumbar myelitis through 1998. Her initial brain MRI in 1989 revealed no abnormality, which met the MRI criteria for multiple sclerosis. In 2009, her serum anti-aquaporin-4 antibody was found to be positive, and a diagnosis of relapsing neuromyelitis optica (NMO) was made on the basis of current diagnostic criteria
We report 12 aquaporin-4 antibody-positive patients Mayo Clinic patients identifiesince 2005) whose initial presenting symptom of neuromyelitis optica was intractable vomiting. The initialevaluation in 75% was gastroenterologic
Devic neuromyelitis optica (DNMO) is a severe demyelinating disease of the central nervous system (CNS).