Autoimmune diseases Monday, April 02, 2012, 17:30 – 19:00 Autologous haematopoietic stem cell transplantation in aggressive forms of neuromyelitis optica (NMO) and NMO spectrum disorders Raffaella Greco, Lucia Moiola, Paolo Rossi, Marta Radaelli, Daniela Ungaro, Massimo Bernardi, Consuelo Corti, Jacopo Peccatori, Attilio Bondanza, Maria Teresa Lupo Stanghellini, Giancarlo Comi, Fabio Ciceri (Milan, IT) ——————————————————————————– Background.
Kevin Weilacher was on vacation when he developed a rare disorder that left him temporarily paralyzed and anxiously awaiting a diagnosis. He and wife, Liz, just celebrated their eighth wedding anniversary in Niagara Falls. While traveling back to Ohio, the couple stopped to visit Weilacher’s mother in Erie, Penn.
Rinsho Shinkeigaku. 2012 Jan;52(1):19-24.
The prevalence of neuromyelitis optica in South East Wales.
Multiple sclerosis: clinical aspects Sunday, May 29, 2011, 12:00 – 13:00 Neuromyelitis optica spectrum disorder: the importance of NMO-IgG in clinical practice M. Radaelli, V
OBJECTIVE: To asses the presence of cortical demyelination in brains of patients with neuromyelitis optica (NMO). NMO is an autoimmune inflammatory demyelinating disease that specifically targets aquaporin-4-rich regions of the CNS. Since aquaporin-4 is highly expressed in normal cortex, we anticipated that cortical demyelination may occur in NMO
Objective: To determine anti-AQP4 antibody status in Thai patients with demyelinating diseases. Methods: Blood samples of patients visiting MS clinic at Siriraj Hospital, Thailand were collected and sent to Tohoku University for testing anti-AQP4 antibodies using AQP4-transfected cell-based assay. Diagnosis was as follows
We describe two patients with recurrent longitudinally extensive transverse myelitis (LETM) associated with human T-lymphotropic virus type I or II (HTLV-I/II) exposure, and with neuromyelitis optica (NMO) immunoglobulin G (IgG) antibody in one case. HTLV-I/II are well known retroviral agents of myelopathy and B-cell dysfunction in humans.
Immune cells cross the inflamed blood–brain barrier. But it’s unclear how brain inflammation begins before immune-cell entry. Studies of a model of multiple sclerosis start to solve this ‘chicken and egg’ conundrum
Abstract Background: Neuromyelitis optica (NMO, Devic syndrome) is an inflammatory disorder of the central nervous system of putative autoimmune etiology that primarily affects the optic nerves and spinal cord. NMO is frequently associated with immunoglobulin G (IgG) antibodies to aquaporin-4 (AQP4-IgG), which are thought to be involved in the pathogenesis of the disease
This report describes the case of a 71-year-old woman with a limited form of neuromyelitis optica (NMO) who had a longitudinally extensive spinal cord lesion from the fourth to the tenth thoracic vertebrae.
In a subgroup of patients with neuromyelitis optica (NMO), a severe inflammatory demyelinating disorder of autoimmune origin characterized by recurrent attacks of optic neuritis and longitudinally extensive transverse myelitis, a parainfectious pathogenesis may play a central role.