Proteomic analysis of the cerebrospinal fluid in multiple sclerosis and neuromyelitis optica patients Authors: Shoufeng Jiang, Jiong Wu, Yi Yang, Jianren Liu, Yao Ding, Meiping Ding Affiliations: Department of Neurology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R.
PURPOSE: To better understand the pathophysiological mechanisms underlying neuromyelitis optica (NMO), we developed a proteomics platform for biomarker discovery in the cerebrospinal fluid (CSF) of patients with NMO.
Neuromyelitis optica (NMO; Devic’s disease) and the NMO spectrum disorders are idiopathic inflammatory demyelinating disorders that affect the central nervous system and have a predilection for optic nerves and spinal cord. The identification of NMO-IgG as a disease-specific marker and aquaporin 4 as the target antigen has renewed interest in NMO.