Neuromyelitis Optica: An Antibody-Mediated Disorder of the Central Nervous System Jiwon Oh and Michael Levy Department of Neurology, Johns Hopkins University School of Medicine, 600 N. Wolfe Street, Pathology 509, Baltimore, MD 21287, USA Received 7 July 2011; Revised 4 October 2011; Accepted 13 October 2011 Academic Editor: Philippe Cabre Copyright ? 2012 Jiwon Oh and Michael Levy
Introduction ? Neuropathic pain is a complex, chronic pain state that usually is accompanied by tissue injury. With neuropathic pain, the nerve fibers themselves may be damaged, dysfunctional or injured.
AQP4 water channels are thought to be the target of autoimmune attack in neuromyelitis optica-spectrum disorders (NMOsd). AQP4 are highly expressed on ventricular ependyma.