Brain Involvement in Neuromyelitis Optica Spectrum Disorders Koon Ho Chan, MD, FRCP; C. T. Tse, MBBS, MRCP; C.
Transverse Myelitis: Symptoms, Causes and Diagnosis Joanne Lynn, M.D. Transverse myelitis (TM) is a neurologic syndrome caused by inflammation of the spinal cord. TM is uncommon but not rare.
The complement system is essential in the pathogenesis of inflammatory central nervous system disorders.
Objective: To determine anti-AQP4 antibody status in Thai patients with demyelinating diseases. Methods: Blood samples of patients visiting MS clinic at Siriraj Hospital, Thailand were collected and sent to Tohoku University for testing anti-AQP4 antibodies using AQP4-transfected cell-based assay. Diagnosis was as follows
Neuromyelitis optica (NMO) is a severe inflammatory demyelinating disease often associated with a highly specific autoantibody, aquaporin-4 antibody.
OBJECTIVE: To analyze the magnetic resonance imaging (MRI) characteristics of neuromyelitis optica (NMO) in Chinese patients. METHODS: We retrospectively reviewed the MRI films of 61 patients with NMO (including 57 female and 4 male patients) admitted in our department
Background: Neuromyelitis Optica (NMO) and its spectrum disorders (NMOSD), which include recurrent transverse myelitis (rTM) and recurrent optic neuritis (rON) are demyelinating diseases of the central nervous system (CNS).
OBJECTIVE. Our goal was to describe the spectrum of clinical phenotypes, laboratory and imaging features, and treatment in pediatric patients with neuromyelitis optica.PATIENTS AND METHODS
Background: Although neuromyelitis optica has been traditionally regarded as a disease without brain involvement, brain abnormalities are not uncommon in patients with neuromyelitis optica-related disorders.Methods: We aimed to characterize the brain magnetic resonance imaging (MRI) abnormalities in neuromyelitis optica spectrum disorder patients who are seropositive for anti-aquaporin-4 autoantibody (AQP4 Ab). Of 236 consecutive patients with inflammatory demyelinating central nervous system diseases, we retrospectively analyzed MRI characteristics of 78 patients who were seropositive for AQP4 Ab.Results: For an average observational period of 6.3 years, 62 patients (79%) had brain lesions on MRI