Evaluation of a Multiparametric Immunofluorescence Assay for Standardization of Neuromyelitis Optica Serology Letizia Granieri,#1,2,* Fabiana Marnetto,#1,2 Paola Valentino,1,2 Jessica Frau,3 Agata Katia Patanella,4 Petra Nytrova,5 Patrizia Sola,6 Marco Capobianco,1 Sven Jarius,7 and Antonio Bertolotto1,2 Author information ? Article notes ? Copyright and License information ? Go to: Abstract.
Frederic Blanc1,2,3*, Vincent Noblet4, Barbara Jung1,3, François Rousseau4, Felix Renard2,4, Bertrand Bourre1,2, Nadine Longato1,3, Nadjette Cremel1,3, Laure Di Bitonto1,3, Catherine Kleitz1,3, Nicolas Collongues1,2, Jack Foucher5, Stephane Kremer2,6, Jean-Paul Armspach2, Jerome de Seze1,2 1 Neuropsychology Service, Department of Neurology, University Hospital of Strasbourg, Strasbourg, France, 2 LINC (Cognitive Neurosciences and Imagery Laboratory), UMR 7237, University of Strasbourg and CNRS, Strasbourg, France, 3 CMRR (Memory Resource and Research Centre), Department of Neurology, University Hospital of Strasbourg, Strasbourg, France, 4 LSIIT (Image Science, Computer Science and Remote Sensing Laboratory), UMR 7005, University of Strasbourg and CNRS, Strasbourg, France, 5 INSERM U666, University Hospital of Strasbourg, Strasbourg, France, 6 Neuroradiology service, University Hospital of Strasbourg, Strasbourg, France Abstract Top Neuromyelitis optica (NMO) is an inflammatory disease of central nervous system characterized by optic neuritis and longitudinally extensive acute transverse myelitis.
Background: Neuromyelitis Optica (NMO) serology is a powerful tool for differential diagnosis from Multiple Sclerosis (MS). This study aims to perform a post-marketing evaluation of the first indirect immunofluorescence assay (IIFA) commercially available for NMO serology
OBJECTIVE: To describe a patient with neuromyelitis optica (NMO) whose aquaporin 4 (AQP4) antibody levels increased following treatment with interferon beta. DESIGN: Prospective clinical and laboratory case report. SETTING: Institutional referral center for multiple sclerosis (MS)