Distinct lesion morphology at 7-T MRI differentiates neuromyelitis optica from multiple sclerosis. Sinnecker T, Dörr J, Pfueller CF, Harms L, Ruprecht K, Jarius S, Brück W, Niendorf T, Wuerfel J, Paul F. Source From the NeuroCure Clinical Research Center (T.S., J.D., C.F.P., J.W., F.P.), Clinical and Experimental Multiple Sclerosis Research Center (J.D., C.F.P., L.H., K.R., F.P.), and Department of Neurology (L.H., K.R.), Charité-Universitaetsmedizin Berlin, Berlin; Division of Molecular Neuroimmunology, Department of Neurology (S.J.), University of Heidelberg, Heidelberg; Department of Neuropathology (W.B.), University Medical Center Göttingen, Göttingen; Berlin Ultrahigh Field Facility (T.N., J.W.), Max Delbrueck Center for Molecular Medicine, Berlin; Institute of Neuroradiology (J.W.), University of Luebeck, Luebeck; and Experimental and Clinical Research Center (T.N., F.P.), Charité-Universitaetsmedizin Berlin and Max Delbrueck Center for Molecular Medicine, Berlin, Germany
Frederic Blanc1,2,3*, Vincent Noblet4, Barbara Jung1,3, François Rousseau4, Felix Renard2,4, Bertrand Bourre1,2, Nadine Longato1,3, Nadjette Cremel1,3, Laure Di Bitonto1,3, Catherine Kleitz1,3, Nicolas Collongues1,2, Jack Foucher5, Stephane Kremer2,6, Jean-Paul Armspach2, Jerome de Seze1,2 1 Neuropsychology Service, Department of Neurology, University Hospital of Strasbourg, Strasbourg, France, 2 LINC (Cognitive Neurosciences and Imagery Laboratory), UMR 7237, University of Strasbourg and CNRS, Strasbourg, France, 3 CMRR (Memory Resource and Research Centre), Department of Neurology, University Hospital of Strasbourg, Strasbourg, France, 4 LSIIT (Image Science, Computer Science and Remote Sensing Laboratory), UMR 7005, University of Strasbourg and CNRS, Strasbourg, France, 5 INSERM U666, University Hospital of Strasbourg, Strasbourg, France, 6 Neuroradiology service, University Hospital of Strasbourg, Strasbourg, France Abstract Top Neuromyelitis optica (NMO) is an inflammatory disease of central nervous system characterized by optic neuritis and longitudinally extensive acute transverse myelitis.
Brain Involvement in Neuromyelitis Optica Spectrum Disorders Koon Ho Chan, MD, FRCP; C. T. Tse, MBBS, MRCP; C.
OBJECTIVE: To investigate the feature brain damage and clinical manifestations in neuromyelitis optica (NMO) patients; To investigate the relationship between serum NMO-IgG antibody and NMO brain damage. METHODS: Clinical data of 37 NMO patients and their head and spinal cord MRI by 1.5T superconducting MR scanner, were analyzed; serum NMO-IgG antibody were measured by immunofluorescence. RESULTS: 17 cases were found to have abnormal signals on MRI, which were mainly in the white matter, pons, medulla, ventricle, aqueduct, and around the corpus callosum; According to pathological changes, brain damage can be divided into scattered irregularity (13 cases), fusion (3 cases), multiple sclerosis-like (1 case), with scattered irregularity more common, 5 cases had clinical manifestations of brain damage: somnolence, vomiting, diplopia, visual rotation, 11 cases patients with brainstem damage show positive serum NMO-IgG antibodies
Objective: To compare spinal cord diffusion tensor imaging (DTI) between multiple sclerosis (MS) and neuromyelitis optica (NMO) subjects with a remote clinical episode of transverse myelitis (TM).
We retrospectively analyzed and compared patterns of anti-aquaporin-4 (AQP4) immunoreactivity of autopsied brains of 2 patients with classical multiple sclerosis (MS) and 2 patients with neuromyelitis optica (NMO). Serological examination for NMO-IgG was not performed in all the cases. We confirmed that the expression of AQP4 is strongly inhibited in demyelinating lesions of NMO, accompanied by the loss of grial fibrillary acidic protein (GFAP) expression
OBJECTIVE: Neuromyelitis optica (NMO) is an inflammatory disease associated with optic neuritis and myelitis. Although some studies have reported multiple sclerosis (MS)-like lesions in 10-30% of NMO patients, brain MRI is usually normal. Several studies have observed metabolic abnormalities on MR spectroscopy in MS, even in normal-appearing white matter (NAWM).