Beneficial Plasma Exchange Response in Central Nervous System Inflammatory Demyelination Setty M.
MS-Related Disorders ID’d by Proteomic Pattern Analysis Last Updated: September 19, 2011. CSF proteomic pattern analysis discriminates among multiple sclerosis-related disorde Proteomic pattern analysis of cerebrospinal fluid analysis using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry distinguishes between similar multiple sclerosis-related disorders, according to a study published online Sept.
Beneficial Plasma Exchange Response in Central Nervous System Inflammatory Demyelination Setty M. Maga?a, BS; B.
Koji Shinoda Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan Takuya Matsushita Department of Clinical Neuroimmunology, Graduate School of Medical Sciences, Kyushu University, Japan Konosuke Furuta Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan Noriko Isobe Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan Tomomi Yonekawa Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan Yasumasa Ohyagi Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan Jun-ichi Kira kira@neuro.med.kyushu-u.ac.jp Department of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Japan Abstract This report describes, for the first time, an occurrence of wall-eyed bilateral internuclear ophthalmoplegia (WEBINO) in a 19-year-old female with neuromyelitis optica (NMO) spectrum disorder, who had anti-aquaporin-4 (AQP4) antibody. A high signal intensity lesion on T2-weighted MRI was detected in the midbrain tegmentum adjacent to the aqueduct, and presumably involved the medial longitudinal fasciculus bilaterally at the caudal levels. Plasma exchange resolved both WEBINO syndrome and the midbrain lesion
Neuromyelitis optica (NMO, Devic’s disease), an uncommon demyelinating neuro-immunological disease, can be associated with autoimmune diseases. In SLE associated forms anti-aquaporin-4 antibody positivity can help differentiating between SLE nerve system manifestation and NMO.
We identified the autoantibody against phosphoglycerate mutase 1 (PGAM1), which is a glycolytic enzyme, in sera from multiple sclerosis (MS) patients by proteomics-based analysis. We further searched this autoantibody in sera from patients with other neurological diseases. The prevalence of the anti-PGAM1 antibody is much higher in patients with MS and neuromyelitis optica (NMO) than in those with other neurological diseases and in healthy controls.
In order to clarify the immunological characteristics of multiple sclerosis (MS) and neuromyelitis optica (NMO), we analyzed CD3, CD4, CD8, CD20, CD4(+)CD25(+), CD4(+)CD29(+), and CD8(+)CD11a(high) cells in peripheral blood from patients with MS (16 stable, 6 active) and NMO (15 stable, 7 active), as well as 9 with NMO spectrum, 6 with clinically isolated syndrome (CIS), and 13 with other neurological diseases using flow cytometry. Significant decreases in the numbers of CD8(+) CD11a(high) cells were observed in stable and active MS and CIS
To investigate differences in helper T cell immune responses in cerebrospinal fluid (CSF) between neuromyelitis optica (NMO) and multiple sclerosis (MS), we measured CSF levels of interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor-alpha and interferon-gamma at the time of relapse in 17 NMO patients and 21 MS patients using fluorescence-activated cell sorting. CSF IL-6 levels were significantly higher in NMO patients than in patients with MS (P = 0.001) and other neurological diseases (P = 0.001).
There are no specific treatments for patients with acute, severe neurological deficits caused by neuromyelitis optica (NMO) who fail to recover after treatment with high-dose corticosteroids. We evaluated the clinical response of anti-tuberculosis treatment (ATT) in patients suffering from steroid-refractory NMO, and investigated the correlation between NMO and tuberculous infection of the central nervous system (CNS)