Proteomic analysis of the cerebrospinal fluid in multiple sclerosis and neuromyelitis optica patients Authors: Shoufeng Jiang, Jiong Wu, Yi Yang, Jianren Liu, Yao Ding, Meiping Ding Affiliations: Department of Neurology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P.R.
Dian He a , c , Qizhu Wu b , Xiuying Chen a , Daidi Zhao a , Qiyong Gong b and Hongyu Zhou a , , a Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China b Department of Radiology, Huaxi MR Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China c Department of Neurology, Affiliated Hospital of Guiyang Medical College, Guiyang, Guizhou Province, China Accepted 27 May 2011.? Available online 1 July 2011. ? Abstract The objective of this study investigated cognitive impairments and their correlations with fractional anisotropy (FA) and mean diffusivity (MD) in patients with neuromyelitis optica (NMO) without visible lesions on conventional brain MRI during acute relapse.
OBJECTIVE: To asses the presence of cortical demyelination in brains of patients with neuromyelitis optica (NMO). NMO is an autoimmune inflammatory demyelinating disease that specifically targets aquaporin-4-rich regions of the CNS. Since aquaporin-4 is highly expressed in normal cortex, we anticipated that cortical demyelination may occur in NMO
Anti-aquaporin-4 (Aqp-4) antibody and complement system have emerged as major pathogenic factors in neuromyelitis optica (NMO). To test the significance of interleukin-6 (IL-6), another important humoral immunity factor, in NMO pathogenesis, we measured serum and cerebrospinal fluid (CSF) IL-6 levels of 23 NMO, 11 transverse myelitis, 16 optic neuritis, 27 relapsing remitting multiple sclerosis patients, and 20 neurologically normal controls
Background: The burden of multiple sclerosis (MS) includes fatigue, depression and worsening of health-related quality of life (HRQOL).
Sir, We report a 9-yr-old girl with a severe relapsing–remitting course of neuromyelitis optica (NMO) [who had a dramatic and -sustained improvement over a 2-yr period of treatment with mycophenolate mofetil (MMF), the prodrug of mycophenolic acid. A 9-yr-old Caucasian girl, previously healthy, was admitted to A.