J Neuroimmunol. 2013 Jan 15;254(1-2):76-82. doi: 10.1016/j.jneuroim.2012.09.010. Epub 2012 Sep 29. Asgari N, Khorooshi R, Lillevang ST, Owens T. Source Neurobiology, Institute of Molecular Medicine,…
Asgari N, Khorooshi R, Lillevang ST, Owens T. Source Neurobiology, Institute of Molecular Medicine, University of Southern Denmark, J.B. Winsloewsvej 25, DK-5000 Odense C, Denmark;…
Recurrent attacks of optic neuritis and myelitis are the hallmarks of both neuromyelitis optica (NMO) and multiple sclerosis (MS). NMO immunoglobulin G (NMO-IgG), which recognizes astrocytic aquaporin-4 (AQP4) water channels, is a specific serum autoantibody that distinguishes NMO from MS. The pathogenic role of the anti-AQP4 antibody (AQP4-Ab, NMO-IgG) in NMO has been speculated based on several studies in vitro.