Background: Epidemiological studies have identified ethnicity-based prevalence differences of NMO which is considered to be rare in Caucasians. However, little is actually known about NMO in Caucasians and NMO may be misdiagnosed.
Introduction: idiopathic acute transverse myelitis (ATM) is clinically characterized by partial or complete spinal cord syndromes, variable remission rate and a monophasic or recurrent clinical course. Partial forms are traditionally associated with Multiple Sclerosis (MS) while complete myelitis to neuromyelitis optica (NMO). The discovery of an antibody called anti-AQP4 was an important tool to differentiate these two conditions.
Objective: To estimate the frequency and prognostic value of NMO-IgG seropositivity in patients presenting with isolated optic neuritis (ON) and no prior neurological events. Background: The aquaporin-4-specific autoantibody, NMO-IgG, is a biomarker for neuromyelitis optica (NMO). We have shown that 38% of patients with longitudinally extensive transverse myelitis (LETM) and 20% of recurrent ON are seropositive and are at high risk for recurrence of ON and myelits
Objetive: To demonstrate the occurrence of intractable hiccup and nausea (IHN) as first symptoms in Neuromyelitis optica (NMO) patients who developed cervical myelitis. Background: IHN are unique symptoms of NMO, which is a neurological disorder mainly characterized by optic neuritis and myelitis. Methods: We reviewed the medical records of 25 cases of relapsing NMO seen at the Ramos Mejia Hospital in Argentina during the period from 2006 to 2010.
Background: Although it has been well established that vaccination does not increase the risk of relapse in patients with multiple sclerosis (MS), no study on the influence of immunization on neuromyelitis optica spectrum disorder (NMOsd) has been conducted. As NMO differs from MS in a number of aspects, including its immunopathogenetic mechanisms, vaccination may have some influence on the occurrence of new relapses
Background: Neuromyelitis optica (NMO) is an inflammatory disorder of the central nervous system predominantly affecting the optic nerves and spinal cord with severe relapses resulting devastating disability.
Background: NMO-IgG autoantibody is now considered a useful serum biomarker of neuromyelitis optica (NMO). A series of clinical and pathological observations suggest that NMO-IgG may play a central role in NMO physiopathology. Objective: The aim of this in vitro-based study was to characterize molecular and functional consequences of interaction between NMO-IgG and primary cultures of astrocytes.
OBJECTIVE: In the present study, we examined some demographic and clinical features of Turkish LDDD patients and we compared these features with Turkish conventional MS patients, on the basis of demographic, clinical and immunological features. BACKGROUND: So called limited disseminated demyelinating diseases (LDDDs) includes optic neuritis (ON), transverse myelitis (TM), optic-spinal multiple sclerosis (OSMS) and neuromyelitis optica (NMO). OSMS and NMO select the involvement of optic nerve and spinal cord more than conventional multiple sclerosis (CMS)
Purpose: Paroxysmal tonic spasms (PTS) are brief, stereotypic, repetitive events of painful dystonic posturing that occur in association with multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). They are a hallmark of central nervous system demyelination and are putatively due to ion channel dysfunction on or adjacent to demyelinated axons
OBJECTIVE: The serum of most neuromyelitis optica (NMO) patients contains autoantibodies (NMO-IgGs) directed against the aquaporin-4 (AQP4) water channel located on astrocyte foot processes in the perivessel and subpial areas of the brain. Our objectives were to determine the source of central nervous system (CNS) NMO-IgGs and their role in disease pathogenesis. METHODS: Fluorescence-activated cell sorting and single-cell reverse transcriptase polymerase chain reaction were used to identify overrepresented plasma cell immunoglobulin (Ig) sequences in the cerebrospinal fluid (CSF) of an NMO patient after a first clinical attack
OBJECTIVE. Our goal was to describe the spectrum of clinical phenotypes, laboratory and imaging features, and treatment in pediatric patients with neuromyelitis optica.PATIENTS AND METHODS
Background: Neuromyelitis optica (NMO) is a rare inflammatory disease. Average age at onset is 35 years. Few data exist on patients with pediatric-onset NMO (p-NMO), with disease onset before age 18 years.