We report a 25-year-old woman who developed optic neuritis and encephalomyelitis following primary Sjogren’s syndrome (SjS).
There are two distinct subtypes of multiple sclerosis (MS) in Asians: opticospinal (OSMS) and conventional (CMS). OSMS has similar features to neuromyelitis optica (NMO) and half of OSMS patients have the NMO-Immunoglobulin G (IgG)/ anti-aquaporin-4 (AQP4) antibody.
BACKGROUND: Antibodies to aquaporin-4 (AQP4) are found in a fraction of Japanese opticospinal multiple sclerosis (OSMS) patients. However, it remains unknown whether anti-AQP4 antibody-positive and negative OSMS patients possess an identical disease
Brain lesions are not uncommon in neuromyelitis optica (NMO) patients with anti-aquaporin-4 (AQP4) antibody; however, the appearance of these lesions is said to be different from that of those in Western patients with multiple sclerosis (MS). To clarify the similarities and dissimilarities of brain lesions in anti-AQP4 antibody-positive and -negative MS and NMO patients, we examined the presence of anti-AQP4 antibody in the sera of 148 consecutive patients fulfilling Poser’s criteria for clinically definite MS, of whom 38 also met the revised NMO criteria, using an immunofluorescence method, and analyzed brain lesions by magnetic resonance imaging (MRI)
Abstract Background: Neuromyelitis optica (NMO, Devic syndrome) is an inflammatory disorder of the central nervous system of putative autoimmune etiology that primarily affects the optic nerves and spinal cord. NMO is frequently associated with immunoglobulin G (IgG) antibodies to aquaporin-4 (AQP4-IgG), which are thought to be involved in the pathogenesis of the disease
A full-term female neonate was born with severe hypotonia and weakness. Her mother had been treated for neuromyelitis optica (Devic disease) for 6 years
A 21-year-old right-handed woman suffered cervical myelitis in 1971, followed by two episodes of bilateral optic neuritis and four relapses of thoracic or lumbar myelitis through 1998. Her initial brain MRI in 1989 revealed no abnormality, which met the MRI criteria for multiple sclerosis. In 2009, her serum anti-aquaporin-4 antibody was found to be positive, and a diagnosis of relapsing neuromyelitis optica (NMO) was made on the basis of current diagnostic criteria
OBJECTIVE: To investigate the differential diagnostic value of NMO-IgG for neuromyelitis optica (NMO) versus multiple sclerosis (MS) and to analyze its possible clinical features related to NMO-IgG. METHODS: Forty-one NMO patients and 44 MS patients in acute phase and 40 healthy controls were investigated. Serum NMO-IgG was tested by indirect immunofluorescence assay.
Background: Neuromyelitis optica (NMO) is characterized by severe optic neuritis and transverse myelitis. Aquaporin-4 (AQP4) antibody is a diagnostic biomarker of NMO
Objectives: Neuromyelitis optica (NMO) is an uncommon but life-threatening demyelinating disorder. With the discovery of the NMO antibody in 2004, diagnostic criteria have been revised
Background and Objective: Our objective was to characterize the clinical and radiologic features of Korean pediatric patients with relapsing central nervous system (CNS) demyelination disease.