Research Contrasting disease patterns in seropositive and seronegative neuromyelitis optica: A multicentre study of 175 patients.
This report describes the case of a 71-year-old woman with a limited form of neuromyelitis optica (NMO) who had a longitudinally extensive spinal cord lesion from the fourth to the tenth thoracic vertebrae.
Objective: To estimate the frequency and prognostic value of NMO-IgG seropositivity in patients presenting with isolated optic neuritis (ON) and no prior neurological events. Background: The aquaporin-4-specific autoantibody, NMO-IgG, is a biomarker for neuromyelitis optica (NMO). We have shown that 38% of patients with longitudinally extensive transverse myelitis (LETM) and 20% of recurrent ON are seropositive and are at high risk for recurrence of ON and myelits
BACKGROUND: Neuromyelitis optica (NMO) is a serious idiopathic inflammatory demyelinating disorder characterized by acute transverse myelitis and optic neuritis. A significant proportion of NMO patients are seropositive for NMO-IgG, an autoantibody targeting aquaporin-4 (AQP4) water channel. Paraneoplastic NMO associated various tumors were recently reported.
BACKGROUND: In 70-80% of cases, neuromyelitis optica (NMO) is associated with highly specific serum auto-antibodies to aquaporin-4 (termed AQP4-Ab or NMO-IgG).
Background: Although neuromyelitis optica has been traditionally regarded as a disease without brain involvement, brain abnormalities are not uncommon in patients with neuromyelitis optica-related disorders.Methods: We aimed to characterize the brain magnetic resonance imaging (MRI) abnormalities in neuromyelitis optica spectrum disorder patients who are seropositive for anti-aquaporin-4 autoantibody (AQP4 Ab). Of 236 consecutive patients with inflammatory demyelinating central nervous system diseases, we retrospectively analyzed MRI characteristics of 78 patients who were seropositive for AQP4 Ab.Results: For an average observational period of 6.3 years, 62 patients (79%) had brain lesions on MRI