Clinical Study Brain MRI abnormalities in Brazilian patients with neuromyelitis optica Cíntia Elias Piresa, b, , , Christianne Martins Correa da Silvaa, Fernanda Cristina Rueda Lopesa, b, Fabiola Rachid Malfetanoa, Valéria C.S.R. Pereiraa, Tadeu Kubob, Paulo R.V. Bahiaa, Soniza Vieira Alves-Leona, Emerson L.
Neuromyelitis optica in a patient with pemphigus foliaceus. Salazar R, Cerghet M, Farhat E, Lim HW
Interstim Therapy InterStim therapy is a pacemaker for the bladder used to reestablish appropriate nueromodulation of the bladder. The device works by using a stimulator device in the buttocks to stimulate the S3 nerve root in the pelvis. This is the primary nerve root for bladder function.
In neuromyelitis optica (NMO), B-cell autoimmunity to aquaporin-4 (AQP4) has been shown to be essential. However, the role of T cells remains ambiguous
Objectives: the aim of our study was to investigate whether the presence of IgG-NMO antibody is associated with a different pattern of response at visual evoked potentials (VEPs) in patients affected by neuromyelites optica spectrum of disorders (NMOsd) with optic neuritis (ON). Methods: we retrospectively studied clinical, immunological and neurophysiological data from 28 patients affected by NMOsd who presented at least one optic neuritis (16 patients bilateral and 12 unilateral).
Background: Neuromyelitis optica is an autoimmune disease usually restricted to spinal cord and optic nerves. Recently, an immunological marker (NMO-IgG) directed against the aquaporin-4 (AQP4) has been found in this disease. Although it usefulness in NMO diagnosis was established, its correlation with disease activity and its interest for NMO follow up was not demonstrated yet
There is evidence that the presence of Aquaporin-4 is directly involved in the pathogenesis ofNMO. AQP-4 Ab is thought to bind to an extra-ceLlular domain of the target protein and the E-loop was suggested as a probable candidate epitope. Molecular mimicry namely structural similarity between epitopes contained within microbial and host proteins, leading to cross-reactive Ab’s in the host has been discussed.
Background: Neuromyelitis optica (NMO) is a neurological disease characterized by optic neuritis and transverse myelitis with long spinal cord lesion. Recently, NMO-IgG, which recognizes the aquaporin-4 (AQP-4), was identified in sera from patients with NMO. AQP-4 is a water channel expressed in astrocytes and ependymal cells throughout the brain and spinal cord
Background: Neuromyelitis optica (NMO) is assumed to be immunologically distinct from multiple sclerosis (MS). Adequate studies about cytokines and chemokines in NMO have been lacking.Objective: To investigate the contribution of cytokines/chemokines in the pathogenesis of NMO.Methods: We measured 27 cytokines/chemokines and Th17 cell-associated cytokines in the cerebrospinal fluid (CSF) of 31 NMO, 29 MS and 18 other non-inflammatory neurological disorders patients. The serum levels of some cytokines/chemokines were also measured.