Case Reports in Medicine Volume 2011 (2011), Article ID 393568, 4 pages doi:10.1155/2011/393568 Case Report Neuromyelitis Optica Spectrum Disease with Positive Autoimmune Indices: A Case Report and Review of the Literature M.
Optimized Azathioprine Can Be Effective for Neuromyelitis Optica Weight-based dosing, laboratory monitoring for biologic effect, and concurrent use of prednisone are important for treatment success. Azathioprine is often used to prevent relapses in patients with neuromyelitis optica (NMO), but data on its efficacy are limited.
Background: Longitudinally extensive transverse myelitis (LETM) is defined clinically by acute transverse myelitis (ATM) and radiologically by extensive spinal cord (SC) lesions spanning three or more vertebral segments on Magnetic Ressonance Image (MRI). Even that LETM carries a considerable diagnostic challenge, has been regarded as a spectrum of Neuromyelitis optica (NMO). The seropositivity for NMO IgG, a specific biomarker of NMO, is variable in LETM patients around the world and reach 30-35% in brazilian series.
Neuromyelitis optica has not been thoroughly studied in Brazilian patients following the discovery of NMOIgG and its specific antigen aquaporin-4.
Background: Neuromyelitis optica (NMO) is an autoimmune inflammatory demyelinating disorder characterized by recurrent attacks of optic neuritis and longitudinally extensive transverse myelitis(LETM). Lower urinary tract symptoms (LUTS) such as voiding dysfuntion are disturbing in LETM patients and has not been studied in this specific population