Brain Involvement in Neuromyelitis Optica Spectrum Disorders Koon Ho Chan, MD, FRCP; C. T. Tse, MBBS, MRCP; C.
OBJECTIVE: To investigate the feature brain damage and clinical manifestations in neuromyelitis optica (NMO) patients; To investigate the relationship between serum NMO-IgG antibody and NMO brain damage. METHODS: Clinical data of 37 NMO patients and their head and spinal cord MRI by 1.5T superconducting MR scanner, were analyzed; serum NMO-IgG antibody were measured by immunofluorescence. RESULTS: 17 cases were found to have abnormal signals on MRI, which were mainly in the white matter, pons, medulla, ventricle, aqueduct, and around the corpus callosum; According to pathological changes, brain damage can be divided into scattered irregularity (13 cases), fusion (3 cases), multiple sclerosis-like (1 case), with scattered irregularity more common, 5 cases had clinical manifestations of brain damage: somnolence, vomiting, diplopia, visual rotation, 11 cases patients with brainstem damage show positive serum NMO-IgG antibodies
Objective: To compare spinal cord diffusion tensor imaging (DTI) between multiple sclerosis (MS) and neuromyelitis optica (NMO) subjects with a remote clinical episode of transverse myelitis (TM).
Introduction: The association between susceptibility to MS and class II alleles of the major histocompatibility complex (MHC) is well established in MS patients but not in NMOR. The ethnicity has an important role in MS HLA DQ and DR profile. Brazilian population has ethnic particularities with a high mixed African and Caucasian Mediterranean population
Background: Neuromyelitis optica (NMO) is an inflammatory idiopathic and usually relapsing disease of the central nervous system, with a characteristic predilection for the optic nerves and spinal cord. MS exhibits a higher prevalence in Caucasian populations, whereas NMO is relatively more frequent in non-Caucasian individuals – Asians, Hispanics and Africans. Brazilian population represents interethnic crossings between people from America, Africa and Europe.
OBJECTIVE. Our goal was to describe the spectrum of clinical phenotypes, laboratory and imaging features, and treatment in pediatric patients with neuromyelitis optica.PATIENTS AND METHODS